A ruthenium(II) anthraquinone complex as the theranostic agent combining hypoxia imaging and HIF-1Î± inhibition

Article ID	Journal	Published Year	Pages	File Type
5151812	Inorganica Chimica Acta	2017	8 Pages	PDF

Abstract

A ruthenium (II) anthraquinone complex Ru-ipad can not only detect repeated cycles of hypoxia-normoxia but also display hypoxia-targeted antitumor effects.152

Keywords

Hcy HIF-1α Cys DTT GSH IC50 NADPH 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide MTT Multicellular tumor spheroids dithiothreitol Ruthenium(II) complex Ruthenium Cysteine Antitumor half-maximal inhibitory concentration homocysteine Hypoxia Probe reduced glutathione

Related Topics

Physical Sciences and Engineering Chemistry Inorganic Chemistry

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A ruthenium(II) anthraquinone complex as the theranostic agent combining hypoxia imaging and HIF-1Î± inhibition

Authors

Jinquan Wang, Junfeng Kou, Xiaojuan Hou, Zizhuo Zhao, Hui Chao,