| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5151850 | Inorganica Chimica Acta | 2016 | 9 Pages |
Abstract
Rhodium metalloinsertors selectively target DNA base pair mismatches, leading to the ejection of the mismatched bases from the DNA Ï-stack. The selective binding of metalloinsertors to DNA mismatches provides the basis for targeting mismatch-repair deficient cells as a strategy for new chemotherapeutic design.47
Keywords
MNNGHDPAPCNAbpyMMREGFRDIP1,10-Phenanthroline2,2′-Bipyridine2,2′-dipyridylaminedhfrDPEN-methyl-N′-nitro-N-nitrosoguanidineProliferating Cell Nuclear AntigenEnzyme-linked immunosorbent assayELISAmismatch repairdihydrofolate reductaserhodiuminductively coupled plasma-mass spectrometryICP-MSPhenDNA probeEpidermal growth factor receptor
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Kelsey M. Boyle, Jacqueline K. Barton,