| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152340 | Journal of Inorganic Biochemistry | 2017 | 27 Pages |
Abstract
Cu2+ and Fe3+ overloads produce respiratory inhibition and phospholipid peroxidation in mitochondria. While the HO
- formation by a Fenton/Haber-Weiss reaction is the responsible mechanism for Fe3+ cytotoxicity, Cu2+ also reacts with thiol groups and glutathione (GSH) since supplementation with GSH leads to full protection probably through formation of Cu(I)-(GSH)2 complexes.87
- formation by a Fenton/Haber-Weiss reaction is the responsible mechanism for Fe3+ cytotoxicity, Cu2+ also reacts with thiol groups and glutathione (GSH) since supplementation with GSH leads to full protection probably through formation of Cu(I)-(GSH)2 complexes.87
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Christian Saporito-Magriñá, Rosario Musacco-Sebio, Juan M. Acosta, SofÃa Bajicoff, Paola Paredes-Fleitas, Sofia Reynoso, Alberto Boveris, Marisa G. Repetto,