| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152390 | Journal of Inorganic Biochemistry | 2017 | 30 Pages |
Abstract
Zinc depletion triggers promyelocytic leukemia protein-retinoic acid receptor alpha (PML-RARα) degradation via the proteasome pathway and induces apoptosis in NB4 cells. Autophagy may play a protective role in PML-RARα degradation triggered by zinc depletion. The crosstalk between zinc and nitric oxide pathway is important for PML-RARα stability.178
Keywords
C-PTIOCHXTris-buffered saline with Tween-20TBSTPEPDAPIPML-RARATPENDAF-FM DAmTORATOAPLLC3BPVDFN,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamineqPCRPBS4-Amino-5-Methylamino-2′,7′-Difluorofluorescein DiacetateatRAarsenic trioxideall-trans retinoic acidApoptosiscycloheximideAPL, acute promyelocytic leukemiaPhosphate-buffered salinesodium nitroprussideNitric oxidemammalian target of rapamycinZinc homeostasisquantitative real-time PCRmicrotubule-associated protein 1 light chain 3 betaPropidium iodidePolyvinylidene fluoridePepstatinSNPChloroquine
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Bo Zhu, Jia-yu Wang, Jun-jie Zhou, Feng Zhou, Wei Cheng, Ying-ting Liu, Jie Wang, Xiao Chen, Dian-hua Chen, Lan Luo, Zi-Chun Hua,