| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152398 | Journal of Inorganic Biochemistry | 2017 | 12 Pages |
Abstract
Protonation equilibria and binding mode of Cu(II) ions by a synthetic hormone - goserelin acetate (Gos) were studied using potentiometry, UV-Vis, CD and theoretical calculations. Cytotoxicity of compounds was studied towards cancer cell lines. The A549 line: (a) control, (b) Cu(II)-Gos; the CT26 line: (c) control, (d) Cu(II)-Gos.338
Keywords
A549GOSInositol trisphosphateIP3HPGGnRHRTRFGoserelinGLPCT26FDAFBSDMEMHypothalamus-pituitary-gonadal axisnDMAPBSGnRHcAMPDFTDulbecco's modified Eagle MediumMTTROSCyclic adenosine monophosphateAscorbic acidAcetic acidPyroglutamic acidHACfluorescein diacetatefetal bovine serumCopper(II) complexesPhosphate-buffered salineDensity functional theoryThyrotropin releasing hormoneGonadotropin-releasing hormonehASCPropidium iodidegoserelin acetateReactive oxygen species
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Paulina K. Walencik, Kamila Stokowa-SoÅtys, Robert Wieczorek, Urszula K. Komarnicka, Agnieszka KyzioÅ, MaÅgorzata Jeżowska-Bojczuk,