| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152454 | Journal of Inorganic Biochemistry | 2017 | 14 Pages |
Abstract
Six triruthenium complexes ([Ru3O(CH3COO)6(L)3]PF6; LÂ =Â azanaphthalenes) were investigated toward their trypanocidal activity. Complex 6 (LÂ =Â 5,6,7,8-tetrahydroisoquinoline) showed lower IC50 values than the reference drug for both trypomastigote (1.30) and amastigote (1.06) forms of T. cruzi. High Selectivity Index values (160 and 209, respectively) make compound 6 an outstanding candidate for in vivo tests.213
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Bruna Possato, Zumira Aparecida Carneiro, Sérgio de Albuquerque, Sofia Nikolaou,