| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152516 | Journal of Inorganic Biochemistry | 2016 | 38 Pages |
Abstract
The phosphane copper(I) complex [Cu(thp)4][PF6], 1 (thp = tris(hydroxymethyl)phosphane) undergoes phosphane dissociation upon dilution, and interacts with methionine-rich peptide sequences comprised in the extra-cellular portion of a human copper transporter. Excess of exogenous copper is then observed in 1-treated cancer cells.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
![Insights into the cytotoxic activity of the phosphane copper(I) complex [Cu(thp)4][PF6]](/preview/png/5152516.png "First Page Preview: Insights into the cytotoxic activity of the phosphane copper(I) complex [Cu(thp)4][PF6]")
Authors
Francesco Tisato, Cristina Marzano, Valentina Peruzzo, Matteo Tegoni, Marco Giorgetti, Marko Damjanovic, Angela Trapananti, Alessandro Bagno, Carlo Santini, Maura Pellei, Marina Porchia, Valentina Gandin,