| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152526 | Journal of Inorganic Biochemistry | 2016 | 11 Pages |
Abstract
A platinum-acridine derivative spontaneously forms a complex with multi-walled carbon nanotubes in aqueous buffers. This drug delivery system induces cytotoxic effects distinct from the free drug including severe replication stress and cell death without initiation of apoptosis. The nanotube enables chemo-photothermal cancer therapy with enhanced cell killing following brief laser exposure.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Cale D. Fahrenholtz, Song Ding, Brian W. Bernish, Mariah L. Wright, Ye Zheng, Mu Yang, Xiyuan Yao, George L. Donati, Michael D. Gross, Ulrich Bierbach, Ravi Singh,