Axially-modified paddlewheel diruthenium(II,III)-ibuprofenato metallodrugs and the influence of the structural modification on U87MG and A172 human glioma cell proliferation, apoptosis, mitosis and migration

Article ID	Journal	Published Year	Pages	File Type
5152527	Journal of Inorganic Biochemistry	2016	11 Pages	PDF

Abstract

The synthesis and characterization of new axially-modified paddlewheel structured diruthenium(II,III)-ibuprofenato metallodrugs are described. The new compounds and the known chlorido-metallodrug were investigated for the effects on U87MG and A172 human glioma cell proliferation, apoptosis, mitosis, and cell migration in vitro.

Keywords

DCM GBM FCS AAS ATR IBP TOF ICP-AES mRNA DSC ESI-MS DTG EtOH LMCT NSAID ACN HSA NIR PBS FDA DMEM COX Metallodrug Diruthenium EDXRF OTF SCF TGA DFT DMSO Dulbecco's modified Eagle's medium VIs human serum albumin cyclooxygenase Ethanol EDTA Acetonitrile Electrospray Ionization Mass Spectrometry Ultraviolet Energy dispersive x-ray fluorescence spectrometry ind Attenuated total reflectance Thermogravimetric analysis Derivative thermogravimetric Non-steroidal anti-inflammatory drugs CNS Dichloromethane Dimethylsulfoxide messenger ribonucleic acid time of flight Self-consistent field World Health Organization Food and Drug Administration fetal calf serum HEW Human glioma cells central nervous system FTIR inductively coupled plasma atomic emission spectroscopy Atomic absorption spectroscopy Mass spectrometry Non-steroidal anti-inflammatory drug Phosphate buffered saline Fourier transformed Infrared Visible Ibuprofen Near infrared Methanol Hen egg white MeOH Density functional theory ZINDO Metal-metal bond Differential scanning calorimetry WHO Glioblastoma