| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152536 | Journal of Inorganic Biochemistry | 2017 | 9 Pages |
Abstract
A series of Pt(IV) prodrugs containing glutamine-like ligands was designed to exploit the increased demand of glutamine showed by some cancer cells. A complex of the series demonstrated a selective accumulation in A549 cancer cells where, upon reduction, it releases cisplatin preventing any possible extrusion by amino acid transporters.430
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Mauro Ravera, Elisabetta Gabano, Stefano Tinello, Ilaria Zanellato, Domenico Osella,