| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152542 | Journal of Inorganic Biochemistry | 2017 | 48 Pages |
Abstract
Cytotoxic redox-active copper complexes with functionalized bidentate nitrogen donor ligands and exchangeable chlorides are described. These compounds bind to albumin but interact weakly with DNA. The complexes cleave DNA in the presence of reducing agents and generate reactive oxygen species in cells.255
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Kathleen E. Prosser, Stephanie W. Chang, Felix Saraci, Phuc H. Le, Charles J. Walsby,