| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152543 | Journal of Inorganic Biochemistry | 2017 | 16 Pages |
Abstract
The three-dimensional topographic map based on a CYP3A4-related construct reveals the majority (88%) of prospective key determinants dictating allosteric effects in P450-catalyzed oxidations to reside within the six known substrate recognition sites clustering either close to the heme face or in the periphery of the enzyme structure.80
Keywords
CLO7-benzyloxyquinolineAFBDAPITC9-Cis-retinoic acidRMSPOREcz(S)-NaproxenPNPSRS9-ethynylphenanthreneADXCLT4MPANFEFVMDZ4-methylpyrazoleKCZFLAPYR7-ethoxyresorufinPDC7-ethoxy-4-trifluoromethylcoumarin4-Cholesten-3-oneBQACyPNADPH-cytochrome P450 oxidoreductaseCbzINB1-PyrenebutanolATDNAPNIR7-ethoxycoumarinéconazoleEfavirenzp-Nitrophenolα-NaphthoflavoneadrenodoxinAflatoxin B1AnilineAllosteric effectsEryErythromycin AEORFluorescence resonance energy transferFRETindIndoleChotestosteroneCooperativityWardapsonediazepamMolecular dynamicsroot-mean-squaresubstrate recognition sitecytochrome b5Cytochrome P450Musclelauric acidMolecular modelingmultiple sequence comparison by log-expectationSTAMPMidazolamNile RedPalmitic acidProgesteroneSingle nucleotide polymorphismPyreneSNPcarbamazepineIsothermal titration calorimetryKetoconazolecholesterolclotrimazoleAID
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Peter Hlavica,