| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5152566 | Journal of Inorganic Biochemistry | 2016 | 11 Pages |
Abstract
Cd activated inositol 1,4,5-trisphosphate receptors (IP3R) to cause the decreased endoplasmic reticulum Ca2Â + concentration ([Ca2Â +]ER) and elevated cytosolic Ca2Â + concentration ([Ca2Â +]c), while changes of [Ca2Â +]ER and [Ca2Â +]c could regulate autophagy and apoptosis. Moreover, Cd-induced reactive oxygen species (ROS) production resulted in autophagy inhibition, which promoted apoptosis.116
Related Topics
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Inorganic Chemistry
Authors
Fei Liu, Zi-Fa Li, Zhen-Yong Wang, Lin Wang,