Bioorganometallic chemistry: Co-factor regeneration, enzyme recognition of biomimetic 1,4-NADH analogs, and organic synthesis; tandem catalyzed regioselective formation of N-substituted-1,4-dihydronicotinamide derivatives with [Cp*Rh(bpy)H]+, coupled to c

The binding of the biomimetic 1,4-NADH co-factor, followed by a 6-membered ring transition state, hydride transfer to the (HLAD)Zn metal center, to provide the putative chiral (HLADH)Zn-H, which reacts with the re face of the prochiral ketone to form the chiral Zn-OR intermediate, and is then released by a proton, or replaced by the 1,4-NADH biomimetic co-factor, to generate the S-chiral alcohol.140