An expeditious and solvent free synthesis of azine derivatives using sulfated anatase–titania as a novel solid acid catalyst

Solid acid catalyst sulfated anatase–titania (TiO2–SO42−) has been used for the synthesis of azine derivatives from benzophenone hydrazone and ketones/aldehydes by simple physical grinding. This sulfated titania gives an excellent yield with short reaction time and is an inexpensive, easily recyclable catalyst for this reaction.

Graphical abstractSulfated anatase–titania (TiO2–SO42−) is reported for the synthesis of azine derivatives in excellent yield by simple physical grinding of reactants at room temperature.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Azines have attracted great attention in organic synthesis. ► TiO2 possesses a unique type of surface involving both redox and acid–base sites. ► Easy product isolation and catalyst reusability make this reaction eco-friendly.