Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5156779 | Carbohydrate Polymers | 2017 | 24 Pages |
Abstract
The physicochemical and powder properties of citrus pectins varying in molecular weight and degree of esterification (DE) were characterized. All the pectins were flake particles with average sizes of around 84-107 μm in diameter. They were amorphous solids and classified as being from slightly to moderately hygroscopic. Pomelo pectin possessed passable to poor flowability while the others were classified as having fair flowability. Heckel's analysis indicated that all pectins underwent plastic deformation under compression. Pectin with a lower%DE and higher molecular weight produced higher tensile strength tablets. The swelling kinetics of all pectins during the first 4 h demonstrated Fickian diffusion and the gel erosion in distilled water of higher%DE pectin was slower. Pectins, at 10% w/w in theophylline matrix tablets, provided fast drug release while those at 50% w/w, delayed drug release which reached 97-100% within 6-8 h.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Parichat Chomto, Jurairat Nunthanid,