Modified bacterial cellulose based self-healable polyeloctrolyte film for wound dressing application

In this investigation, we prepare a self-healable polyelectrolyte film via crosslinking the cationically charged chitosan (Cts) with anionically modified bacterial cellulose (BC), which is a green source of nano-filler. This polyelectrolyte film is able to show dynamic self-healing activity at physiological pH condition via adapting ionic interaction, a state of non-covalent bond. BC was prepared using Glucanoacetobacter xylinus (MTCC7795) bacteria and after that its surface was modified with anionic poly(acrylic acid) using “grafting from” technique. It was observed that the notch (single and multiple) created over the composite film was disappeared by showing vibrant diffusion and ionic interlocking in contact with buffer solution having physiological pH. The XTT assay revealed that the composite film is non-toxic in nature and it was witnessed that the composite film was capable of delivering curcumin, a hydrophobic drug that has an ability to show antimicrobial activity and wound healing capability.