Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5157248 | Carbohydrate Polymers | 2017 | 11 Pages |
Abstract
Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60 mg/kg, oral) for 14 days significantly reduced the tumor weight and volume compared with controls. Treatment with 60 mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway.
Keywords
NAGNaOAcALTBcl-2FADDGAPDHTMBmRNAMTXp53Walker-256 tumorRIP-1NF-κBSFPMLKLMPODNAROSASTAspartate aminotransferaseAlanine aminotransferaseEthanolSodium acetatedeoxyribonucleic acidBaxtetramethylbenzidineANOVAImmunomodulationtumor necrosis factor-alphamessenger ribonucleic acidRed wineVascular Endothelial Growth Factor (VEGF)TNF-αnuclear factor kappa BCabernet francB-cell lymphoma 2MetotrexatomyeloperoxidaseNecroptosisHematoxylin and EosinKetamine hydrochlorideParaffinprotein 53Bcl-2-associated X proteinmixed lineage kinase domain-like proteinreceptor-interacting protein kinase 1Receptor-interacting Protein Kinase 3Polysaccharideglyceraldehyde 3-phosphate dehydrogenaseReactive oxygen species
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maria Carolina Stipp, Iglesias de Lacerda Bezerra, Claudia Rita Corso, Francislaine A. dos Reis Livero, Luiz Alexandre Lomba, Adriana Rute Cordeiro Caillot, Aleksander Roberto Zampronio, José Ederaldo Queiroz-Telles, Giseli Klassen, Edneia A.S. Ramos,