| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5157488 | Carbohydrate Polymers | 2017 | 31 Pages |
Abstract
Here we demonstrate that cyclodextrins could be used as a bisphosphonate carrier. The formation of cyclodextrins-bisphosphonate complexes was characterized by 1D and 2D NMR spectroscopy, Isothermal Titration Calorimetry and UV-vis spectroscopy. The results revealed that only the side chain of bisphosphonate was involved in the inclusion phenomenon and its length was a crucial parameter in the control of affinity. Findings from this study suggest that cyclodextrin will be a useful carrier for bisphosphonates.
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Authors
Maelle Monteil, Marc Lecouvey, David Landy, Steven Ruellan, Isabelle Mallard,