| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5157529 | Carbohydrate Polymers | 2017 | 22 Pages |
Abstract
The covalent grafting of two amino-fullerene C60 derivatives (C60-LC-NH2 and C60-SC-NH2, LCÂ =Â long chain and SCÂ =Â short chain) onto the surface of TEMPO oxidized nanocrystalline cellulose (NCC-COOH) has been reported for the first time. These hybrids (NCC-LC-C60 and NCC-SC-C60) form stable colloidal suspensions at concentrations up to 0.5Â mg/mL and act as effective photosensitizers for singlet oxygen production as demonstrated by the oxidation of L-methionine-methyl ester to the corresponding sulphoxide. Using the same approach, in a one-pot reaction both a fluorescent target molecule (FITC-LC-NH2) and the C60-LC-NH2 derivative have been successfully attached covalently onto the NCC-COOH surface. These hybrids, which showed no cytotoxicity on MCF-7 human breast cancer cells could be good candidates in photodynamic cancer therapy.
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Authors
A. Herreros-López, M. Carini, T. Da Ros, T. Carofiglio, C. Marega, V. La Parola, V. Rapozzi, L.E. Xodo, Ali A. Alshatwi, C. Hadad, M. Prato,