Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5157602 | Carbohydrate Polymers | 2017 | 31 Pages |
Abstract
Biocompatible and biodegradable polyurethanes (PUs) based on polycaprolactone diol (PCL) were prepared and filled with cellulose nanowhiskers (CNWs) obtained from wastepaper. The incorporated polyurethane nanocomposites were used to prepare foamed scaffolds with bimodal cell sizes through solvent casting/particulate leaching method. Sodium chloride and sugar porogens were also prepared to fabricate the scaffolds. The mechanical and thermal properties of PU/CNW nanocomposites were investigated. Incorporation of different CNWs resulted in various structures with tunable mechanical properties and biodegradability. All bimodal foam nanocomposites were biodegradable and also non-cytotoxic as revealed by MTT assay using SNL fibroblast cell line. PU/CNW foam scaffolds were used for osteogenic differentiation of human mesenchymal stem cells (hMSCs). Based on the results, such PU/CNW nanocomposites could support proliferation and osteogenic differentiation of hMSCs in three-dimensional synthetic extracellular matrix (ECM).
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Authors
Ehsan Shahrousvand, Mohsen Shahrousvand, Marzieh Ghollasi, Ehsan Seyedjafari, Iman Sahebi Jouibari, Amir babaei, Ali Salimi,