| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5157793 | Carbohydrate Polymers | 2017 | 27 Pages |
Abstract
The present research work demonstrated that the diverse pharma grade hyaluronan fragments could modulate cellular processes differently. From 1800Â kDa down to 50Â kDa, CD44 was the recognized receptor and pro-inflammatory biomarkers were only slightly up-regulated during wound healing in the presence of HA. Finally our outcomes showed that the lower the fragment size the higher the concern for inflammatory cytokines up-regulation; repair process impairment was highlighted only for 6Â kDa chains.
Keywords
TNFαtime-lapse video microscopyHaCaTinflammatory biomarkerLHAqRT-PCRNaClPBSDMEMTGF-β1FBScDNAComplementary DNADulbecco’s modified Eagle mediumribonucleic acidRNAMolecular sizetransforming growth factor beta 1tumor necrosis factor αquantitative real time PCRSodium chloridefetal bovine serumHhaHyaluronicMolecular weighthigh molecular weightlow molecular weightReceptors
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Antonella D'Agostino, Antonietta Stellavato, Luisana Corsuto, Paola Diana, Rosanna Filosa, Annalisa La Gatta, Mario De Rosa, Chiara Schiraldi,