Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5157813 | Carbohydrate Polymers | 2017 | 11 Pages |
Abstract
The purpose of this work was designed to investigate the hepatoprotective and antioxidant effects of enzymatic-extractable mycelia zinc polysaccharides (En-MZPS) from Pleurotus eryngii var. tuoliensis on the hyperlipidemic mice induced by high-fat-high-cholesterol emulsion (HFHCM). The results showed that the supplementation of En-MZPS had potential anti-hyperlipidemia effects on reducing hepatic lipid levels by monitoring the serum enzyme activities (ALP, ALT and AST) and serum lipid levels (TC, TG, HDL-C, LDL-C and VLDL-C), enhancing the antioxidant enzymes (SOD, GSH-Px, CAT and T-AOC), and decreasing the lipid peroxidation (MDA and LPO). Furthermore, the in vitro scavenging results indicated that the inhibition effects of En-MZPS on hydroxyl radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals reached 59.98 ± 6.29% and 37.01 ± 2.15%, respectively. These conclusions demonstrated that the En-MZPS might be suitable for functional foods and natural drugs in preventing the HFHCM-induced hyperlipidemia and non-alcoholic fatty liver.
Keywords
MDAT-AOCXylGSH peroxidealamine aminotransferaseRHAVLDL-CHDL-CLDL-CCATALTLPOArabinoseGSH-PxROSASTALPAlkaline phosphataseaspertate aminotransferasesuperoxide anionHepatoprotective effectstriglycerideARARibrhamnoseRiboseSODSuperoxide dismutaseTotal antioxidant capacityhigh-density lipoprotein cholesterolmalondialdehydeMannoseprotManLipid peroxidationProteinCatalaseGas chromatographytotal cholesterolVery low-density lipoprotein cholesterollow density lipoprotein cholesterolNormal controlPositive controlModel controlGalGalactoseXyloseGluGlucoseReactive oxygen species
Related Topics
Physical Sciences and Engineering
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Authors
Nuo Xu, Zheng Gao, Jianjun Zhang, Huijuan Jing, Shangshang Li, Zhenzhen Ren, Shouxian Wang, Le Jia,