Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
51581 | Catalysis Communications | 2011 | 4 Pages |
A new type of phosphate-pyridine (P, N) ligand derived from d-glucosamine and BINOL was synthesized and successfully applied in Cu-catalyzed enantioselective conjugate addition of diethylzinc to chalcones for the first time, high yields and enantioselectivities were obtained when the ligand 10a which contains (S)-BINOL was used. The results also showed that the configuration of BINOL at the ligand backbone had remarkable effects on the activities and enantioselectivities.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A new type of P,N ligand which derived from D-glucosamine was synthesized. ► It has been successfully used in asymmetric 1,4-conjugate addition reactions. ► The configuration of BINOL at the ligand have effect on the reaction was proved.