Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5158220 | European Journal of Medicinal Chemistry | 2017 | 41 Pages |
Abstract
1-Phenyl-pyrazole-4-carboxylic acid derivatives were synthesized and evaluated as xanthine oxidoreductase inhibitors. Compound 16c was a mixed-type xanthine oxidoreductase inhibitor with an IC50 of 5.7Â nM and a considerable hypouricemic effect similar to febuxostat in mice.160
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Organic Chemistry
Authors
Jing Li, Fangping Wu, Xingguo Liu, Yake Zou, Huixiong Chen, Zheng Li, Lei Zhang,