| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5158235 | European Journal of Medicinal Chemistry | 2017 | 53 Pages |
Abstract
A series of novel 6,11-dihydro-5H-benzo[e]pyrimido[5,4-b] [1,4]diazepine derivatives were designed, synthesised and evaluated for their c-Met kinase inhibition. The promising compound 17f displayed favourable pharmacokinetic properties, an acceptable safety profile, and significant anti-tumour activity in the Caki-1 tumour xenograft model.72
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
![Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors](/preview/png/5158235.png "First Page Preview: Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors")
Authors
Daowei Huang, Lei Huang, Qingwei Zhang, Jianqi Li,