Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of Î±/Î²-peptide foldamers conjugated to cell-penetrating peptides

Article ID	Journal	Published Year	Pages	File Type
5158253	European Journal of Medicinal Chemistry	2017	33 Pages	PDF

Keywords

IC50 PPIs Leishmania infantum SPPS EC50 Foldamers Fluorescein 5-isothiocyanate Protein-protein interaction inhibitors CPP DSSP HCTU trypanothione reductase Enzyme-linked immunosorbent assay ELISA Protein-protein interactions Molecular dynamics Solid phase peptide synthesis selectivity index inhibitory concentration 50 effective concentration 50 Visceral leishmaniasis Proteolysis Propidium iodide polyethylene glycol PEG Cell-penetrating peptide

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of Î±/Î²-peptide foldamers conjugated to cell-penetrating peptides

Authors

Héctor de Lucio, Ana MarÃa Gamo, Marta Ruiz-Santaquiteria, Sonia de Castro, Pedro A. Sánchez-Murcia, Miguel A. Toro, Kilian Jesús Gutiérrez, Federico Gago, Antonio Jiménez-Ruiz, MarÃa-José Camarasa, Sonsoles Velázquez,