First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent inÂ vitro antileishmanial activity#

Article ID	Journal	Published Year	Pages	File Type
5158271	European Journal of Medicinal Chemistry	2017	11 Pages	PDF

Keywords

LC50 trifluorethanol DSSP Helix stabilization PyBOP Protein-protein interaction inhibitors SPPS Leishmania infantum TFE PPIs MMT IC50 CPP trypanothione reductase Enzyme-linked immunosorbent assay ELISA Protein-protein interactions Molecular dynamics Solid phase peptide synthesis Lethal concentration 50 inhibitory concentration 50 Visceral leishmaniasis Propidium iodide Cell-penetrating peptide Peptides cell-penetrating peptides

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent inÂ vitro antileishmanial activity#

Authors

Marta Ruiz-Santaquiteria, Pedro A. Sánchez-Murcia, Miguel A. Toro, Héctor de Lucio, Kilian Jesús Gutiérrez, Sonia de Castro, Filipa A.C. Carneiro, Federico Gago, Antonio Jiménez-Ruiz, MarÃa-José Camarasa, Sonsoles Velázquez,