Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease

Article ID	Journal	Published Year	Pages	File Type
5158288	European Journal of Medicinal Chemistry	2017	49 Pages	PDF

Keywords

tetramethylsilane APP BuChE 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium butyrylcholinesterase HFIP DTNB Autodock Tools TcAChE CAS Aβ AAPH eeAChE PDB Electrophorus electricus AChE ORAC-FL TMS Aβ aggregation inhibitors HEPES MTDLs PBS ADT 1,1,1,3,3,3-hexafluoro-2-propanol MTT ROS β-Amyloid ACh AChE Acetylcholine Acetylcholinesterase ThT Alzheimer's disease Thioflavin T Peripheral anionic site Catalytic active site Antioxidant agents Multifunctional agents Multitarget-directed ligands Phosphate-buffered saline acetylcholinesterase inhibitors PAS Protein Data Bank amyloid precursor protein high-performance liquid chromatography HPLC Reactive oxygen species

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease

Authors

Zhipei Sang, Xiaoming Qiang, Yan Li, Rui Xu, Zhongcheng Cao, Qing Song, Ting Wang, Xiaoyu Zhang, Hongyan Liu, Zhenghuai Tan, Yong Deng,