| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5158353 | European Journal of Medicinal Chemistry | 2017 | 57 Pages |
Abstract
A series of compounds with an introduction of methyl group into N1-position to previous reported 2-arylethenylquinoline analogues were synthesized and evaluated. The optimal compound a12 showed good anti-AD potential.235
Keywords
HT22butyrylcholinesteraseBuChEPBLDTNBPAMPAATCBTCCASAβGSHAAPHCHESFACSacetylthiocholine chlorideORAC6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acidAUCH2DCFDAROSamyloid-βAChEAcetylcholinesteraseTemThTAlzheimer's diseaseAβ aggregationTroloxThioflavin Tfluorescence-activated cell sortingPeripheral anionic siteCatalytic active siteBBBoxygen radical absorbance capacityBlood-brain barrierNeuroprotectionCholinesterase inhibitionTransmission electron microscopyPASCholinesteraseGlutathioneReactive oxygen species
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chun-Li Xia, Ning Wang, Qian-Liang Guo, Zhen-Quan Liu, Jia-Qiang Wu, Shi-Liang Huang, Tian-Miao Ou, Jia-Heng Tan, Hong-Gen Wang, Ding Li, Zhi-Shu Huang,