Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation

Article ID	Journal	Published Year	Pages	File Type
5158366	European Journal of Medicinal Chemistry	2017	22 Pages	PDF

Keywords

HNE DL-glyceraldehyde DHN ARIS ALR2 sorbitol dehydrogenase NF-κB PKC ALR1 PLC AP-1 1,4-dihydroxynonene iNOS SDH GS-HNE 4-hydroxy-trans-2-nonenal MAPK inducible NO synthase Trifluoroacetylation Aldehyde reductase Aldose reductase nuclear factor kappa-light-chain-enhancer of activated B cells phospholipase C aldose reductase inhibitors activator protein 1 Protein kinase C mitogen-activated protein kinase Gal

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation

Authors

Nikolaos Papastavrou, Maria Chatzopoulou, Jana Ballekova, Mario Cappiello, Roberta Moschini, Francesco Balestri, Alexandros Patsilinakos, Rino Ragno, Milan Stefek, Ioannis Nicolaou,