Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor

Article ID	Journal	Published Year	Pages	File Type
5158399	European Journal of Medicinal Chemistry	2017	20 Pages	PDF

Keywords

Shanghai Synchrotron Radiation Facility SAR SSRF JAK2 P-TEFb BRD4 inhibitor Janus Kinase 2 PTMs PLK1 bromodomain and extra-terminal Fluorescence anisotropy post-translational modifications Structure-activity relationship BET Positive transcription elongation factor b Polo-like kinase 1 Kac Kinase

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor

Authors

Jianping Hu, Yingqing Wang, Yanlian Li, Lin Xu, Danyan Cao, ShanShan Song, Mohammadali Soleimani Damaneh, Xin Wang, Tao Meng, Yue-Lei Chen, Jingkang Shen, Zehong Miao, Bing Xiong,