Discovery of pentacyclic triterpene 3Î²-ester derivatives as a new class of cholesterol ester transfer protein inhibitors

Article ID	Journal	Published Year	Pages	File Type
5158450	European Journal of Medicinal Chemistry	2017	13 Pages	PDF

Keywords

SAR LXR VLDL FXR HDL-C PTS LDL-C ACAT 4-dimethylaminopyridine TLC DMAP EDCI CETP PLS 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride CVDs farnesoid X receptor PPARs Pentacyclic triterpenes Dyslipidemia Cardiovascular diseases triglyceride Structure activity relationship non-HDL-C Pancreatic lipase very-low-density lipoprotein Low density lipoprotein-cholesterol High density lipoprotein-cholesterol CETP inhibitor cholesteryl ester transfer protein liver X receptor thin layer chromatography high performance liquid chromatography HPLC cholesteryl ester total cholesterol Peroxisome proliferator-activated receptors

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Discovery of pentacyclic triterpene 3Î²-ester derivatives as a new class of cholesterol ester transfer protein inhibitors

Authors

Dongyin Chen, Xin Huang, Hongwen Zhou, Hanqiong Luo, Pengfei Wang, Yongzhi Chang, Xinyi He, Suiying Ni, Qingqing Shen, Guoshen Cao, Hongbin Sun, Xiaoan Wen, Jun Liu,