Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia

Article ID	Journal	Published Year	Pages	File Type
5158488	European Journal of Medicinal Chemistry	2017	11 Pages	PDF

Keywords

CDK STAT5 fms-like tyrosine kinase MNK PI3K PIGF iMAP FLT3 ITD SFK GI50 ERK mTOR FLT3 inhibitor TKD AML Janus kinase eIF Src family kinase MAPK Dual inhibitor internal tandem duplication Tyrosine kinase domain placental growth factor Eukaryotic Initiation Factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)signal transducer and activator of transcription 5 Phosphatidylinositol 3-kinase Acute myeloid leukaemia inhibition constant mammalian target of rapamycin mitogen-activated protein kinase JAK Drug discovery extracellular signal-regulated kinase cyclin-dependent kinase

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia

Authors

Sarah Diab, Ahmad M. Abdelaziz, Peng Li, Theodosia Teo, Sunita K.C. Basnet, Ben Noll, Muhammed H. Rahaman, Jingfeng Lu, Jinqiang Hou, Mingfeng Yu, Bich T. Le, Hugo Albrecht, Robert W. Milne, Shudong Wang,