| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5158532 | European Journal of Medicinal Chemistry | 2017 | 37 Pages |
Abstract
By rational design and modification, compound 9m showed excellent HDACs inhibitory activity, strong anti-proliferative activity against human cancer cell lines including RMPI 8226 and HCT 116. Moreover, compound 9m noticeably up-regulated the level of histone H3 acetylation at the low concentration of 0.3 μM.189
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jiang Wang, Mingbo Su, Tingting Li, Anhui Gao, Wei Yang, Li Sheng, Yi Zang, Jia Li, Hong Liu,