| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5158553 | European Journal of Medicinal Chemistry | 2017 | 31 Pages |
Abstract
Coordination of 6a,b with Pt(II) resulted in complexes 7a,b with enhanced cytotoxicity. The complexes exerted cytotoxic effects towards cancer cells by inducing apoptosis, possibly through non-covalently binding to DNA.120
Keywords
poly(ADP-ribose)polymerase 1Room temperature.PARP1CDDPMTSDAPI3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt4′,6-diamidino-2-phenylindolecis-diamminedichloroplatinum(II)DMSOethidium bromideApoptosisdimethyl sulphoxideSynthesisAntiproliferative activityPropidium iodidePlatinum(II) complex
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
You-Shan Li, Bin Peng, Li Ma, Sheng-Li Cao, Lu-Lu Bai, Chao-Rui Yang, Chong-Qing Wan, Hao-Jie Yan, Pan-Pan Ding, Zhong-Feng Li, Ji Liao, Ying-Ying Meng, Hai-Long Wang, Jing Li, Xingzhi Xu,