Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities

Article ID	Journal	Published Year	Pages	File Type
5158562	European Journal of Medicinal Chemistry	2017	56 Pages	PDF

Keywords

DCM MTD DMF PC3 Ac2O IC50 ACN CCRF-CEM DMAD THF LiAlH4 Topoisomerases MDR SAR HCT-116 MEI TOPO β-carboline Lithium aluminium hydride Acetic anhydride Acetonitrile SCLC Tetrahydrofuran Maximum tolerated dose Dimethyl acetylenedicarboxylate dimethylformamide Dichloromethane Structure-activity relationship Human colon cancer NSCLC Small cell lung cancer Non-small cell lung cancer Human prostate cancer Multidrug resistance Topoisomerase inhibition NAH half maximal inhibitory concentration Sodium hydride Propidium iodide DNA cross-linking Cross-linking

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities

Authors

Sue-Ming Chang, Wilson Christian, Ming-Hsi Wu, Tai-Lin Chen, Yi-Wen Lin, Ching-Shu Suen, Hima Bindu Pidugu, Dilip Detroja, Anamik Shah, Ming-Jing Hwang, Tsann-Long Su, Te-Chang Lee,