Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis

Article ID	Journal	Published Year	Pages	File Type
5158660	European Journal of Medicinal Chemistry	2017	27 Pages	PDF

Keywords

PI3K SAR TGF-β ERK1/2 phosphorylation fMLP bFGF BMDCs HUVECS MMP-2 ERK1/2 MAPKs Mitogen activated protein kinases Akt/PKB transforming growth factor-β EMT Structure activity relationship Human umbilical vein endothelial cells bone marrow-derived cells Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)basic fibroblast growth factor Phosphatidylinositol 3-kinase Akt phosphorylation Migration Epithelial-mesenchymal transition

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis

Authors

Elda Meta, Chiara Brullo, Adama Sidibe, Beat A. Imhof, Olga Bruno,