| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5158678 | European Journal of Medicinal Chemistry | 2017 | 26 Pages |
Abstract
Novel bergenin/cinnamic acid hybrids were synthesized and evaluated for their antitumour activity both in vitro and in vivo. The most potent compound, 5c, arrested HepG2 cells (IC50 = 4.23 ± 0.79 μM) in the G2/M phase and induced mitochondria-mediated apoptosis, which could serve as a novel Akt/Bcl-2 inhibitor for further preclinical studies.159
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chengyuan Liang, Shaomeng Pei, Weihui Ju, Minyi Jia, Danni Tian, Yonghong Tang, Gennian Mao,