Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity

Article ID	Journal	Published Year	Pages	File Type
5158748	European Journal of Medicinal Chemistry	2017	40 Pages	PDF

Keywords

SQS PsPP HMG-CoA BHT NSAID FPP HDL NADPH IC50 3-Hydroxy-3-methylglutaryl-CoA BSA bovine serum albumin Antioxidant squalene synthase Benzothiazine Benzoxazine cardiovascular disease triglyceride Triglycerides Room temperature CVD Non-steroidal anti-inflammatory drug farnesyl pyrophosphate high-density lipoprotein cholesterol LDL Morpholine nicotinamide adenine dinucleotide phosphate Hyperlipidemia Multi-target total cholesterol Low-density lipoprotein cholesterol

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity

Authors

Maria G. Katselou, Alexios N. Matralis, Angeliki P. Kourounakis,