(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal Î²-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B

Article ID	Journal	Published Year	Pages	File Type
5158832	European Journal of Medicinal Chemistry	2017	37 Pages	PDF

Keywords

GM1-gangliosidosis Iminosugars pharmacological chaperones

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal Î²-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B

Authors

Sophie Front, Anna Biela-BanaÅ, Patricie Burda, Diana Ballhausen, Katsumi Higaki, Anna Caciotti, Amelia Morrone, Julie Charollais-Thoenig, Estelle Gallienne, Stéphane Demotz, Olivier R. Martin,