Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5158887 | European Journal of Medicinal Chemistry | 2017 | 15 Pages |
Abstract
A series of novel non-covalent piperazine or piperidine-containing dipeptidyl derivatives possessing a neopentyl-asparagine residue, as exemplified by compound 35, were designed and synthesized. Most of the target compounds exhibited potent in vitro, ex vivo and in vivo proteasome inhibitory activities and anti-proliferation activities against two multiple myeloma cell lines. Additionally, the enzymatic stability of target compound was also improved.193
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Authors
Rangxiao Zhuang, Lixin Gao, Xiaoqing Lv, Jianjun Xi, Li Sheng, Yanmei Zhao, Ruoyu He, Xiaobei Hu, Yidan Shao, Xuwang Pan, Shourong Liu, Weiwei Huang, Yubo Zhou, Jia Li, Jiankang Zhang,