ZnO nanofluid as a structure base catalyst for chemoselective amidation of aliphatic carboxylic acids

ZnO nanofluids were synthesized and utilized as a new reaction media in the preparation of amides via direct amidation of aliphatic carboxylic acids with primary amines under solvent-free conditions. High yields and good selectivity are achieved with this psudo-homogeneous catalyst, while the recovered nanoZnO was reusable.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► ZnO nanofluids were originally used as catalyst in the amidation of acids. ► The amount of fluid is important for ZnO nanofluids. ► ZnO nanofluid can be easily prepared and is reusable. ► Aliphatic acids were reacted chemoselectively versus aromatic ones.