Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structureâactivity relationships of the tricyclic quinone skeleton and the oxadiazole substituent

Article ID	Journal	Published Year	Pages	File Type
5158973	European Journal of Medicinal Chemistry	2017	14 Pages	PDF

Keywords

DTPA SAR N,N'-dicyclohexylcarbodiimide Redox activation NADPH-cytochrome P450 oxidoreductase 7-aminoactinomycin D 7-AAD DMAP NQO-1 DCC 4-(Dimethylamino)pyridine NAD(P)H:quinone oxidoreductase 1 ROS CPR Room temperature Diethylenetriaminepentaacetic acid dihydroethidium structure−activity relationship superoxide radical SOD HaCaT cells Superoxide dismutase Antiproliferative activity DHE Quinone Reactive oxygen species

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structureâactivity relationships of the tricyclic quinone skeleton and the oxadiazole substituent

Authors

Atila Basoglu, Simone Dirkmann, Nader Zahedi Golpayegani, Silke Vortherms, Jan Tentrop, Dominica Nowottnik, Helge Prinz, Roland Fröhlich, Klaus Müller,