The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over Î±1-adrenoceptor andÂ D2-like receptor subtypes

Article ID	Journal	Published Year	Pages	File Type
5159018	European Journal of Medicinal Chemistry	2017	44 Pages	PDF

Keywords

GPCR tetramethylsilane TMS EBSS 5-hydroxytriptamine adrenoceptors 8-OH-DPAT ARS ASA SAR 5-HT 5-HT1A receptor 8-hydroxy-2-(di-n-propylamino)tetralin Anxiolytic effect Cho Chinese Hamster Ovary Structure-activity relationship α1-Adrenoceptor subtypes transmembrane Earle's balanced salt solution Docking studies G protein-coupled receptor

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over Î±1-adrenoceptor andÂ D2-like receptor subtypes

Authors

Fabio Del Bello, Alessandro Bonifazi, Mario Giannella, Gianfabio Giorgioni, Alessandro Piergentili, Riccardo Petrelli, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura, Thomas M. Keck, Angelica Mazzolari, Giulio Vistoli, Antonio Cilia, Elena Poggesi,