| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5164125 | Phytochemistry | 2016 | 6 Pages |
Abstract
Bioassay-guided fractionation of an extract from a Hawaiian endophytic fungus Chaetoconis sp. led to the isolation of eight compounds (1-8), including six previously unknown sesquiterpenes, chaetopenoids A-F (1-6). Their chemical structures were determined by HRMS and NMR spectroscopy. All isolates were evaluated for their cytotoxicity against A2780 and cisplatin-resistant A2780 (A2780CisR) cancer cell lines. Dendryphiellin A1 (7) was active against A2780 and A2780CisR cell lines with IC50 values of 6.6 and 9.1 μg/mL, respectively.
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Authors
Chun-Shun Li, Yuanqing Ding, Bao-Jun Yang, Naomi Hoffman, Hong-Quan Yin, Taifo Mahmud, James Turkson, Shugeng Cao,