| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5164280 | Phytochemistry | 2015 | 17 Pages |
Abstract
Xenobiotics that inhibit the cell-wall-remodelling enzyme activity, xyloglucan endotransglucosylase (XET), would be a valuable tool in 'chemical genetics' for elucidating its biological roles. By screening 4216 small molecules in a dot-blot assay on paper-immobilised xyloglucan, we discovered 45 compounds that inhibited or promoted XET activity. The most effective inhibitors were singlet oxygen generators.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dimitra Chormova, Lenka Franková, Andrew Defries, Sean R. Cutler, Stephen C. Fry,