| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5164837 | Phytochemistry | 2013 | 12 Pages |
Abstract
By HPLC-based activity profiling, labdane diterpenoids from Curcuma kwangsiensis were identified as positive GABAA receptor modulators. A total of 11 compounds, among them four new natural products, were characterized. Their interaction with GABAA receptors was established with two-microelectrode voltage-clamp measurements on Xenopus oocytes expressing recombinant α1β2γ2S GABAA receptors. The absolute configuration of labdane diterpenoids was assigned by ECD.
Keywords
Conductor-like Polarizable Continuum ModelECDTCMCurcuma kwangsiensisOPLSZingiberaceaeHPLC-based activity profilingTDDFTElectronic circular dichroism (ECD)CPCMSCRFCotton effectgamma-aminobutyric acidElectronic circular dichroismLabdane diterpenoidsSelf-Consistent Reaction Fieldtraditional Chinese medicineGABA
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anja Schramm, Samad Nejad Ebrahimi, Melanie Raith, Janine Zaugg, Diana C. Rueda, Steffen Hering, Matthias Hamburger,