| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5165177 | Phytochemistry | 2012 | 9 Pages |
Abstract
⺠Ten daphnane diterpenoid orthoesters were isolated from Trigonostemon cherrieri. ⺠They all possess a mono- or dichlorovinyl group on the daphnane core. ⺠They were isolated using bioassay-guided and LC/MS-guided fractionations. ⺠They are a class of non-nucleosidic inhibitor of the DENV NS5 RdRp. ⺠They showed strong antiviral activity against CHIK, Sindbis and Semliki forest virus.
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Authors
Pierre-Marie Allard, Pieter Leyssen, Marie-Thérèse Martin, Mélanie Bourjot, Vincent Dumontet, Cécilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Cyril Poullain, Françoise Guéritte, Marc Litaudon,