Lycorine induces cell death in the amitochondriate parasite, Trichomonas vaginalis, via an alternative non-apoptotic death pathway

Article ID	Journal	Published Year	Pages	File Type
5165579	Phytochemistry	2011	6 Pages	PDF

Abstract

âº The alkaloid lycorine was cytotoxic against the amitochondriate Trichomonas vaginalis. âº Important ultrastructural alterations were observed by electron microscopy. âº Lycorine arrested the T. vaginalis cell cycle. âº Similarities to paraptotic cell death were found. âº Our results contribute to the lycorine mechanisms of action on eukaryotic cells.

Keywords

Amaryllidaceae Alkaloids Parasite Trichomonas vaginalis Lycorine Cell death pathway

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Lycorine induces cell death in the amitochondriate parasite, Trichomonas vaginalis, via an alternative non-apoptotic death pathway

Authors

Raquel Brandt Giordani, PatrÃcia de Brum Vieira, Marina Weizenmann, Denis Broock Rosemberg, Ana Paula Souza, Cristina Bonorino, Geraldo Attilio De Carli, MaurÃcio Reis Bogo, José Angelo Zuanazzi, Tiana Tasca,